Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia

Abstract Background Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. Red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) are prognostic factors to mortality in different diseases. The aim of this study evaluate efficiency RDW, NLR, Sequential Organ Failure Assessment (SOFA) score for prediction respiratory patients with VAP. Results One hundred thirty-six mechanically ventilated developed VAP were included. Clinical characteristics SOFA on day admission at diagnosis VAP, NLR assessed correlated mortality. average age was 58.80 ± 10.53. These variables had a good diagnostic performance AUC 0.811 0.777 0.728 0.840 combined RDW. combination three parameters demonstrated excellent (AUC 0.889). A positive correlation found between RDW ( r = 0.446, P < 0.000) 0.220, 0.010). Conclusions non-specific inflammatory markers that could be calculated quickly easily via routine hemogram examination. have comparable accuracy severity scores. Consequently, simple, yet promising ICU physicians monitoring clinical course, assessment organ dysfunction, predicting patients. Therefore, recommends use blood biomarkers one simplest (SOFA score) rapid critical as daily works ICU.